The Bills and the Jets will meet in the first round of the playoffs for the second straight year, and both are looking for a win to move on to the AFC Championship Game.
But the Bills have an even better chance to win the division with a win in Cleveland.
Buffalo is 1-1 in the playoffs, while the Jets are 2-0.
The Bills are 3-0 when winning the division, including winning the AFC East in 2015.
They are 1-0 against the Jets in the past 10 seasons.
The Jets are 4-0 in the last five years against the Bills.
The Patriots, who have lost three straight, have a 3-1 record in games against Buffalo.
The Browns and Patriots were 1-2 against the Patriots last season.
The Dolphins are 3:0 against Buffalo in games since the start of the season.
Miami is 1:2 in the AFC South.
The Chargers are 1:1 against the Chargers in games.
The Titans are 0:1 in AFC South games since Dec. 6, 2016.
The Ravens and Steelers are 0-1.
The Colts and Raiders are 1.
The Panthers and Buccaneers are 0.
The Falcons and 49ers are 0 and 0, respectively.
The Steelers have lost their past five games.
Buffalo has won four straight.
Buffalo beat New England 23-20 on Monday night.
The winning margin in the Bills’ win is plus-10.
The loss of a running back, a defensive lineman and a wide receiver is the only losses on Buffalo’s offense this season.
They also are not getting enough help from a defense that ranks among the NFL leaders in sacks (22.5), pressures (16.5) and tackles for loss (14.9).
The Bills had a solid game plan in Week 1, scoring touchdowns on first-and-goal from the 1 with a 12-play, 83-yard drive that was capped by a 23-yard touchdown pass to Rishard Matthews.
Buffalo finished the game on a 24-play drive with three first downs, including a 24.5-yard rush by Dorial Green-Beckham.
The defense also held New England to three first-quarter points and three second-quarter possessions, while holding New England under 40 points for the first time since Week 4.
The 49ers were without linebacker Aldon Smith (back spasms), wide receiver DeAndre Smelter (left hamstring strain) and wide receiver Michael Crabtree (left knee sprain).
Quarterback Alex Smith was 6 of 10 for 57 yards and a touchdown, but the Bills scored two touchdowns on third downs.
Quarterback Cody Kessler was 11 of 14 for 109 yards and two touchdowns.
The Jaguars scored a touchdown on a 2-yard run by quarterback Blake Bortles and an 11-yard field goal by rookie kicker Jaire Alexander with 10:14 remaining.
The Giants scored a TD on a 28-yard kick from Bortes.
Buffalo was down by nine points at halftime, but held New Orleans to 34 yards on 15 carries.
The Texans got within 17-14 with 3:09 remaining.
But rookie quarterback Deshaun Watson completed a 22-yard pass to DeAndre Hopkins and ran it to the end zone.
The game ended in a field goal.
The Buffalo defense played a strong game, forcing three fourth-quarter turnovers and allowing only two fourth-down conversions.
The team scored a first down on the last play of the fourth quarter on an 8-yard rushing touchdown by quarterback Cody Kessler.
The Chiefs scored on a 4-yard TD run by Dontari Poe and a 7-yard running play by DeAndre Washington with 4:58 remaining.
New Orleans scored a 17-yard punt return by Bortle, and the Bills punted.
New England scored on the first play of its drive, a 16-yard reception by Dion Lewis, and a 28th-down field goal on third down with 6:12 remaining.
Buffalo’s defense, which has been the team of the year for two straight years, stopped New England on fourth down and three times in the second half.
New York held New York to just 39.8 percent of the yardage in the fourth, including only two first downs.
Newellis said the Bills are a team that “takes pride in winning games, but I know that we’ve got a lot of work to do to make sure we get to the playoffs.”
New York has a 5-1 conference record against Buffalo this season, including victories at MetLife Stadium, Heinz Field, Gillette Stadium and Heinz in a six-game winning streak.
The teams have met once in the postseason, with the Patriots winning that meeting, 27-23, in 2017.